Publications
- C.D. Paul, K. Bishop, A. Devine, E.L. Paine, J.R. Staunton, S.M. Thomas, J.R. Thomas, A.D. Doyle, L.M. Miller Jenkins, N.Y. Morgan, R. Sood, and K. Tanner. Tissue architectural cues drive organ targeting of tumor cells in zebrafish. Cell Systems, in press (2019). Pubmed
- J.R. Staunton, Y.S. Woong, C.D. Paul, and K. Tanner. High-frequency microrheology in 3D reveals mismatch between cytoskeletal and extracellular matrix mechanics in cancer cells. PNAS 116: 14448-14455 (2019). Pubmed
- C.L. Yankaskas, K.N. Thompson, C.D. Paul, M.I. Vitolo, P. Mistriotis, A. Mahendra, V.K. Bajpal, D.J. Shea, K.M. Manto, A.C. Chai, N. Varadarajan, A. Kontrogianni-Konstantopoulos, S.S. Martin, and K. Konstantopoulos. A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens. Nature Biomedical Engineering 3: 452-465 (2019). Pubmed
- C.D. Paul*, A. Devine*, K. Bishop, Q. Xu, W.J. Wulftange, H. Burr, K.M. Daly, C. Lewis, D.S. Green, J.R. Staunton, S. Choksi, Z.-G. Liu, R. Sood, and K. Tanner. Human macrophages survive and adopt activated genotypes in living zebrafish. Nature Scientific Reports 9: 1759 (2019). (*, equal contribution) Pubmed
- C.D. Paul, A. Hruska, J.R. Staunton, H.A. Burr, K.M. Daly, J. Kim, N. Jiang, and K. Tanner. Probing cellular response to topography in three dimensions. Biomaterials 197: 101-118 (2019). Pubmed
- C.D. Paul, P. Mistriotis, and K. Konstantopoulos. Cancer cell motility: lessons from migration in confined spaces. Nature Reviews Cancer 17: 131-140 (2017). Pubmed
- M. Shriver, S. Marimuthu, C. Paul, J. Geist, K. Konstantopoulos, and A. Kontrogianni-Konstantopoulos. Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit. Oncotarget 7: 45414-45428 (2016). Pubmed
- E. Mathieu*, C.D. Paul*, R. Stahl, G. Vanmeerbeeck, V. Reumers, C. Liu , K. Konstantopoulos, and L. Lagae. Lens-free imaging of cell migration in diverse physical microenvironments. Lab on a Chip 165: 3304-3316 (2016). (*, equal contribution) Pubmed
- C.D. Paul, W.-C. Hung, D. Wirtz, and K. Konstantopoulos. Engineered models of confined cell migration. Annual Review of Biomedical Engineering 18: 159-180 (2016). Pubmed
- C.D. Paul, D.J. Shea, M.R. Mahoney, A. Chai, V. Laney, W.-C. Hung, and K. Konstantopoulos. Interplay of the physical microenvironment, contact guidance, and intracellular signaling in cell decision making. The FASEB Journal 30: 2161-2170 (2016). Pubmed
- P. Wang, S.-H. Chen, W.-C. Hung, C. Paul, F. Zhu, P.-P. Guan, D.L. Huso, A. Kontrogianni-Konstantopoulos, and K. Konstantopoulos. Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase-12 via IGF-2 and VEGF signaling pathways. Oncogene 34: 4558-4569 (2015). Pubmed
- P.S. Raman*, C.D. Paul*, K.M. Stroka, and K. Konstantopoulos. Probing cell traction forces in confinement microenvironments, Lab on a Chip 13: 4599-4607 (2013). (*, equal contribution) Pubmed
- W.-C. Hung, S.-H. Chen, C.D. Paul, K.M. Stroka, Y.-C. Lo, J.T. Yang, and K. Konstantopoulos. Distinct signaling mechanisms regulate migration in unconfined versus confined spaces. Journal of Cell Biology 202(5): 807-824 (2013). Selected for F1000Prime and JCB “In Focus” Article. Pubmed
- S.-H. Chen, W.-C. Hung, P. Wang, C. Paul, and K. Konstantopoulos. Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation. Scientific Reports 3: 1870 (2013). Pubmed
- E.M. Balzer, Z. Tong, C.D. Paul, W.-C. Hung, K.M. Stroka, A.E. Boggs, S.S. Martin, and K. Konstantopoulos. Physical confinement alters cell adhesion and migration phenotypes. FASEB Journal 26(10): 4045-4056 (2012). Pubmed
Presentations
- C.D. Paul, K. Bishop, A. Devine, E.L. Paine, J.R. Staunton, S.M. Thomas, J. Thomas, L.M. Miller Jenkins, N.Y. Morgan, R. Sood, and K. Tanner. Differential extravasation patterns drive organ targeting of tumor cells in zebrafish. Oral presentation, CCR Fellows and Young Investigators 2019 Colloquium, National Cancer Institute, Rockville, MD, February 2019.
- C.D. Paul, K. Bishop, A. Devine, W.J. Wulftange, E.L. Paine, J.R. Staunton, S. Shema, V. Bliskovsky, L.M. Miller Jenkins, N.Y. Morgan, R. Sood, and K. Tanner. Tissue architectural cues and differential extravasation patterns drive the non-random trafficking of tumor cells in larval zebrafish. Oral presentation, American Institute of Chemical Engineers Annual Meeting, Pittsburgh, PA, November 2018.
- C.D. Paul, A. Hruska, J.R. Staunton, H.A. Burr, J. Kim, N. Jiang, and K. Tanner. Decoupling Cellular Response to Topography and Stiffness in Three Dimensions. Oral presentation, American Institute of Chemical Engineers Annual Meeting, Pittsburgh, PA, October 2018.
- C.D. Paul, A. Hruska, J.R. Staunton, H.A. Burr, J. Kim, N. Jiang, and K. Tanner. Decoupling Cellular Response to Topography and Stiffness in Three Dimensions. Oral presentation, Biomedical Engineering Society Annual Meeting, Atlanta, GA, October 2018.
- C.D. Paul, K. Bishop, A. Devine, E.L. Paine, J.R. Staunton, S.M. Thomas, L.M. Miller Jenkins, N.Y. Morgan, R. Sood, and K. Tanner. Tissue architectural cues and differential extravasation patters drive the non-random trafficking of tumor cells in larval zebrafish. Oral presentation, CCR Fellows and Young Investigators Association Seminar Series, National Cancer Institute, Frederick, MD, September 2018.
- C.D. Paul, K. Bishop, A Devine, N. Morgan, E. Paine, L. Jenkins, R. Sood, and K. Tanner. In vivo, Multi-Organ Examination of Cancer Cell Trafficking and Extravasation in Early Metastatic Dissemination. Oral presentation, Biomedical Engineering Society Annual Meeting, Phoenix, AZ, October 2017.
- C.D. Paul, A. Devine, and K. Tanner. Tissue-Specific Characterization of Innate and Introduced Immune Cell Migration in Danio rerio. Oral presentation, Biomedical Engineering Society Annual Meeting, Phoenix, AZ, October 2017.
- C.D. Paul, A. Devine, K. Bishop, N. Morgan, R. Sood, M. Gottesman, and K. Tanner. Capillary Arrest and Intravascular Migration in a Zebrafish Model of Early Metastasis. Oral presentation, Biomedical Engineering Society Annual Meeting, Minneapolis, MN, October 2016.
- C.D. Paul, D.J. Shea, M.R. Mahoney, A. Chai, V. Laney, W.-C. Hung, and K. Konstantopoulos. The Interplay of the Physical Microenvironment, Contact Guidance, and Cell Signaling in Cell Decision Making. Oral presentation, Biomedical Engineering Society Annual Meeting, Tampa, FL, October 2015.
- C.D. Paul, E. Mathieu, R. Stahl, G. Vanmeerbeeck, K. Konstantopoulos, and L. Lagae. Single-Cell Lens-Free Imaging of Cell Migration in Diverse Microenvironments. Oral presentation, Biomedical Engineering Society Annual Meeting, Tampa, FL, October 2015.
- C.D. Paul, D.J. Shea, M. Mahoney, W.-C. Hung, and K. Konstantopoulos. Dimensionality and Contact Guidance Affect Tumor Cell Migration and Decision Making. Oral presentation, Biomedical Engineering Society Annual Meeting, San Antonio, TX, October 2014.
- C.D. Paul, P.R. Raman, K.M. Stroka, and K. Konstantopoulos. A Microfluidic Device to Measure Traction Forces During Confined Chemotactic Migration. Oral presentation. American Institute of Chemical Engineers Annual Meeting, San Francisco, CA, November 2013.
- C.D. Paul, P.R. Raman, K.M. Stroka, and K. Konstantopoulos. A Microfluidic Device to Measure Traction Forces During Confined Chemotactic Migration. Oral presentation, Biomedical Engineering Society Annual Meeting, Seattle, WA, September 2013.
- C.D. Paul, E.M. Balzer, Z. Tong, W.-C. Hung, A.E. Boggs, S.S. Martin, and K. Konstantopoulos. Physical Confinement Reduces the Role of Actin-Based Forces in Cell Migration. Poster presentation, Third Annual NCI Physical Sciences-Oncology Centers (PS-OCs) Network Investigators’ Meeting, Tampa, FL, April 2012.
- C.D. Paul and J.A. Hestekin. Pervaporative Recovery of Butanol from Fermentation Broth Using Mixed Matrix Membranes. Oral presentation, American Institute of Chemical Engineers Annual Student Conference, Nashville, TN, November 2009.
- C.D. Paul, M.B. O’Neil, W.R. Penney, B.J. Van Wie, P.B. Golter, R.R. Beitle, and E.C. Clausen. Desktop learning module heat exchanger performance. Oral presentation and conference paper, Proceedings of the 2009 Midwest Section Conference of the American Society for Engineering Education, 2009.
- C.D. Paul and J.A. Hestekin. Pervaporative Recovery of Butanol from Fermentation Broth. Oral presentation, Mid-America Regional American Institute of Chemical Engineers Meeting, Columbia, MO, April 2009.
Patents
- K. Konstantopoulos, C.D. Paul, A. Quinones-Hinojosa, and A. Kontrogianni-Konstantopoulos. Microfluidic chip for analysis of cell motility and methods for using same. United States Patent 10,105,700, 2018.